منابع مشابه
Immobilisation of hydroxynitrile lyases.
Hydroxynitrile lyases are a versatile group of enzymes that are applied both in the laboratory and on an industrial scale. What makes them particularly interesting is that to date five structurally unrelated categories of hydroxynitrile lyases have been discovered. Given their great importance they have often been immobilised utilising many different methodologies. Therefore the hydroxynitrile ...
متن کاملHydroxynitrile lyases: At the interface of biology and chemistry
Hydroxynitrile lyases are the versatile group of enzymes, which play a significant defensive role in plant system against microbial attack. In chemical industries, hydroxynitrile lyase is used as an important industrial biocatalyst for the synthesis of chiral cyanohydrins by exploiting the reversible enzymatic reaction. Cyanohydrins are biologically active compounds used in synthesis of -amino ...
متن کاملEnantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases - a review.
The first enantioselective synthesis was the selective addition of cyanide to benzaldehyde catalysed by a hydroxynitrile lyase (HNL). Since then these enzymes have been developed into a reliable tool in organic synthesis. HNLs to prepare either the (R)- or the (S)-enantiomer of the desired cyanohydrin are available and a wide variety of reaction conditions can be applied. As a result of this, n...
متن کاملHydroxynitrile Lyases, Interesting Biocatalysts in Stereoselective Organic Syntheses
Hydroxynitrile lyases (HNLs) from Prunus amygdalus (PaHNL), Sorghum bicolor (SbHNL), Manihot esculenta (MeHNL) and Hevea brasiliensis (HbHNL) are excellent biocatalysts for the preparation of optically active cyanohydrins. (R)as well as (S)-cyanohydrins are obtained in high optical and chemical yields. The synthetic potential of the now easily available optically pure cyanohydrins is demonstrat...
متن کاملCharacterization of two bacterial hydroxynitrile lyases with high similarity to cupin superfamily proteins.
Hydroxynitrile lyases (HNLs) catalyze the cleavage of cyanohydrins. In the reverse reaction, they catalyze the formation of carbon-carbon bonds by enantioselective condensation of hydrocyanic acid with carbonyls. In this study, we describe two proteins from endophytic bacteria that display activity in the cleavage and the synthesis reaction of (R)-mandelonitrile with up to 74% conversion of ben...
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ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2013
ISSN: 0306-0012,1460-4744
DOI: 10.1039/c3cs35491a